The Menchikov Vaccine Research Institute of the Russian Academy of Medical Sciences
We studied the influence of exposure of living organisms in the pyramid on the organism’s reaction to infection. The study was carried out on a model infection of mice caused by the bacterium called salmonella typhi murium (murine typhus bacillus, the causative agent of salmonellosis).
White, non-pedigree mice weighting 12–14 grammes were exposed in the pyramid for various lengths of time and various numbers of times. After several days the mice were infected peritoneally using four doses of salmonella typhi murium, increasing by a factor of ten from 101 to 104 microbe cells. A control group of mice from the same batch were infected with the same doses of culture, but not exposed in the pyramid.
It was reliably established that the survival rate for the mice exposed in the pyramid is considerably higher than for the control group. At the lower doses 60% of the mice exposed in the pyramid survived, against 7% in the control group. At higher doses the corresponding figures were 30% and 3%.
Conclusion: time spent by mice in the pyramid substantially promotes increased resistance to subsequent infection with salmonella typhi murium. In other words, it is possible to speak of a powerful immuno-modulating effect on the non-specific reactivity of the animals’ organism.
A similar picture was observed when the mice were injected with various carcinogens. Mice in the experimental group drank water exposed in the pyramid; the control group drank ordinary water. The result: the probability of tumours developing in the control group was several times higher than for the animals that drank water exposed in the pyramid.
Laboratory head N.B.Yegorova Ph.D.